Giles,
You can quite easily do the Cape - Cairo trip without a GPS and only using conventional navigation techniques and a Michelin map, but if you want to explore well off the beaten track (and particulalry anywhere in the desert) they are very handy.
As bundubasher said, they are often most useful when entering a new city for the first time, particulalry if you have the co-ordinates of a campground etc.
Garmin World map software is sufficient if you just want the main north-south African routes.
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