Ran 7.50 R16 for about 2 years on Defender. Changed to 265/75/16 BFG MTs for the 7 month trans africa trip. Much better all round tyre, far better than an AT. With defender fully loaded and with higher profile - higher suspension, higher tyres, roll cage, roof rack, roof tent, the large tyres sit far better. Wouldn't go back. However definite downsides as highlighted by Sam of lack of availability and difficulty in carrying spares - tyre to wide to go on bonnet, 265s won't fit on rear double rear wheel carrier which used to carry 7.50 R16s. Hence bit of a pain.
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