In my view the sex are not that important in Sahara. Sure you will have some issues with the locals but in the desert you will probably spend most of the time alone so that part doesn’t matter much.
How hard it will be consist of many factors, like:
-Time of year (temperature)
-Terrain
-How much water and petrol you have to carry
-Type of vehicle
-Your own skills
-Your mental preparation
-Can you expect to get help on that route if anything happens?
As you see most of these points you can influence in the planning-stage by choosing a route and a time of year that fits your vehicle and skills.
If you choose to travel alone bear in mind that from time to time you might feel lonely and if something goes wrong you are completely on your own. Some people, including myself, appreciate this so much that it’s worth the extra risk. Other people prefer to go in a group; a combination might be a good thing.
I think some of the things that are important for a nice trip are:
-Some kind of plan
-A sound vehicle where most things work
-A genuine interest for what you are doing
-Be open-minded don’t over focus on your task, use your time and enjoy
-Knowledge of your vehicle (how to fix a flat tire, normal service procedures etc)
-The skill to handle unexpected problems
-Be curios
-Respect for your bodies signal (tiredness, temporarily weakness, fear etc)
-Good logistic
-Do it because you want to do it, not to prove anything
Nothing here is sex-related, sure you need the physical strength to put your bike back on the wheels when you crash but you can practice before you leave. I’m not an athlete myself (smoking 20 cigarettes a day and I never work out) but I have managed to cross Sahara in summertime – alone, and I will probably do it again.
This is just my personal meaning, IMHO there is no right or wrong. If you want to go then prepare yourself and do it, but take care you might be addicted.