Hi Skyroads,
My opinion is that 3 1/2 weeks is too tight for what you want to do without spending too much time driving.
I am a bit biased since I live in Southern California but I really, really like Little Bikes suggestion, hitting San Diego, the coastal route to San Francisco, (skip LA) Yosemite, the Eastern Sierra Nevada Mountains, Las Vegas, Grand Canyon, etc.
You won't have a rental car one way drop off fee if you do a loop.
At any rate I would focus on a smaller part of the US if you only have 3 1/2 weeks wherever that may be as long as it is seasonally appropriate.
Have a great trip!
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