Sierra foothills, Hwy 49 Motherlode route
From SF go east to Copperopolis, Columbia, etc. and down the Sierra Nevada Mountains through the gold country, down to the Sequoia National Park, Minieral King area, by staying in the national forests you could camp at "wilderness" camp areas or stay a low cost motels along the way, pass through the Mojave Desert Preserve, Joshua Tree, Anza Boreggo and on to Mexico.
If you need more detail drop me a note and I will try to give you some routes and ideas.
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