It is a very good book to travel by. My wife and I have taken many small sections of some of the routes listed. One year we did "The Loneliest Road" US-50 as outlined in that book. From Reno, NV going east to Maryland.
As a outline for a trip it works well but you should get road maps for the areas you are going through. many of the old 2 lane US routes are very congested in and around cities. We will go to the Interstates that have ring-routes around large urban areas.
It sounds like a good trip. Let us know the routes you are taking.
John
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