Having spent time in Alaska in winter/summer and lived in Europe here are my thoughts :
The sheer size and lack of infrastructure, population, services etc of the Last Frontier is beyond comprehension for most; it is over four times the size of Sweden and nearly have the size of the current EU.
It has less than one million population.
When I worked there (late 1990’s) I was told there were more small planes than cars/trucks in Alaska because there are so few roads in the state.
And private planes still regularly go missing never to be found again despite exhaustive searches – it is vast remoteness.
In summer its cool to cold.
In winter its cold to extremely cold and dark most of the day.
Hiking the muskeg is similar to slogging through deep snow – one is completely exhausted within a couple of hours.
The bugs, even with personal protection i.e. deet, bug net etc, can drive you over the edge within one night.
Though bug season can be relatively short.
Scheduling the time of year is obviously critical.
I have no experience with snow kites but it seems like a viable means of transportation in early and late winter to traverse the vast distances with relative ease.
As Mark mentioned river crossings will be challenging unless frozen or you have air transport.
IMHO attempting a bush-whacking hike through Alaska’s backcountry is a non-starter.
If you can piece together a series of existing resource roads, established trails and cut lines with regular air support for supplies you might have a decent chance.
From a Western perspective with enough time and money i.e. technology anything is possible and from an Eastern perspective with the right mind set anything is possible.
Perhaps a combination of both will provide you the means to have a successful crossing.
Check out Karsten’s film on his 1500km trip across the Arctic to get a feel for the conditions.
https://www.youtube.com/watch?v=SsJ3w7hUfLs
HTH and good luck.
Riel