You don't say how long you have to do this, if time is not an issue then Kazakhstan is an off-road / gravel track paradise, just have a look on google earth and plot a route. One nice off-road route takes you from the Kokaral Dam (near Kokaral) across very barren desert south towards the Uzbekistani border, then SW to Beyneu, from where you join a main road.
Mangystau Region )of which Aktau is the capital) is an off-road paradise on a par with Mongolia, again, check Google Maps and make your own route if you like that sort of thing. I can highly recommend the off-road trip trip to the Ustyurt reserve, though you are really on your own out here and will need 400 km (off road) of fuel range and plenty of water / food.
Uzbekistan has far fewer off-rad possibilities, but I can recommend the road heading north out of Navoiy to Zerafshan and Uchquduq, then on to Khiva or Karakalpakstan. It is paved (but rough), but it is extremely remote and goes straight through the heart of the Kyzyl-Kum, far from the Amu Darya.
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EurasiaOverland a memoir of one quarter of a million kilometres by road through all of the Former USSR, Western and Southern Asia.
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