through bolivia is the better and more beautiful way than the interoceanic highway.
the big part in brazil of the interoceanic is really boring and quite sad seeing no rainforest anymore and lots of dead animals close to the road.
the peruvian part is okay. even the street is quite boring and straight for a long time. in puerto maldonado you can do overpriced tours in the rainforest... the best part is when you pass the andes going from 200m up to 4700. thats a really beautiful scenery!
everything is paved!
the pantanal and before bonito is an awesome place on earth! you can take a ferry from the end of the north transpantanal to corumba, heading to bolivia-la paz tititaca and so on. the pantanal fascinate me so much even i´ve been there many time.
the transpantanal routes (north or south, north is more beautiful) isn´t paved. the rest is paved in brazil. the first part in bolivia up to santa cruz is paved afterwards there need to help somebody because is headed to uyuni and not la paz...which could be also a good way for you
other possibility could be heading to manaus and going by boat to leticia. but you will probably know leticia is a dead end city. you need to fly out from there.
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