Hey Neil,
Couple of quick comments, I'm sure your bike is already set up well for you but in case it isn't, I would recommend you spend some time optimizing riding position and tweaking seat height, bar risers, reach, foot pegs, etc. It can make a big difference over long trips, especially if you are trying to reduce strain at a specific point. Shake out rides are good for making incremental changes and seeing how they impact overall comfort.
Also, don't know what bike you have but the vibration of thumper would be something to avoid if your wrists are affected by vibrations. Also, things like foam grips and throttle locks like a throttle rocker can make a big difference in reducing grip fatigue.
Have a great ride.
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