The Taftan border is an important trade hub for the Pakistani's. In the past the border has been closed numerous of times for short periods lasting upto several weeks.
Over the past year there have been executions of shia muslims traveling by bus between Quetta & Taftan. In terms of safety the route has deteriorated considerably. It runs close to the afghan border through a long stretch of desert.
As an alternative have a look at the Bahu Kalat (Iran) - Jewani (Pak) trading border connected by the Makran Highway (N10) to Karachi. This road is brand new connecting the port Gwadar to Karachi.
I know it's less known border post but once questions start to cross this border it can become an alternative to the volatile Taftan border post.
Same for the Zero Border between Turkey - Iran, it's a less known border compared to the busy Dogubajazit border but a good and practical alternative.
Good luck!
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