There is only one border crossing for vehicular traffic between Pakistan and India and that is from Lahore ie Wagah/Atari. It appears Stash that you will have to drive 1200 kms north from Karachi to Lahore first.
You cannot drive straight from Taftan (Irani border) till Karachi via RCD Highway due to law and order problems. If you really want to visit Karachi youl have to stick to the main roads and turn south from Sukkur.
In your plan youl be missing KKH and the north, well its your choice but I wont advise you. You can visit the 5000 years old cities of Moenjodaro and Harrapa on this route.
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