I haven't done that route for a decade or so, but it's a looong way, and can concur that the main roads through Western Sahara and Mauritania are boring straight with little variation of scenery, mainly scrubland. Nevertheless I found it more bearable to slow down, look carefully at what I was passing, and travel at 80 kph rather than 120 kph.
Northern Senegal is also fairly boring, very flat, everywhere looks the same. Very friendly locals, handsome guys, beautiful women, surprisingly expensive—more like Spanish prices than Morocco.
Morocco has dropped all Covid restrictions, so no need for three vaccinations or a PCR. Don't know Mauritania or Senegal restrictions, but you would still be well advised to get a third dose booster (I've now had four doses).
I would definitely take a very loose fitting mossy net, but no need for meds. I've had really bad reactions, and as Chris writes, the risk is low in the winter. I use Avon 'skin so soft' for low level protection, and Boot's Repel (50% Deet) against sand flies and other beasties. Not been to Guinea, so can't help there.
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"For sheer delight there is nothing like altitude; it gives one the thrill of adventure
and enlarges the world in which you live," Irving Mather (1892-1966)
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