Tim is right, AFAIK.
I'm not sure what the Afghanistan "panhandle" means, but if you're looking at the Wahkan, there is no prospect of foreigners being allowed that route into Pakistan even once (i.e., if) the Chinese finish their purported road across a 16,000 ft+ pass.
If you search this site, you'll find lots of reports, along with idle speculation and pure fantasy, about ways to bypass China. There is shipping, for example, between India or Nepal and Thailand, and someday there may or may not again be an overland route from India through Myanmar. You could think about the long way around through Russia, with or without shipping your bikes on the Trans-Siberian train, subject to political considerations. Etc.
Again: do some poking around this site and your plans may come a bit more into focus. At the moment, you seem to be dealing in inaccuracies (c.f., Americans and British in Iran), misunderstandings (the Wakhan), and dreams (a rail route through southern Asia).
Hope that's helpful.
Mark
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