It really helps if you ask more specific questions and describe your situation a bit.
Yes, I have driven the Pamir Highway (and Wakhan route) in October in a 4WD. Up in Karakol it was -15 in the morning, but there was no snow. There was snow on the Kyzyl-Art Pass, but daytime temperatures went above freezing so it did not stay. But weather is fickle, so it could easily be covered in a nice carpet of snow.
Will it be cold? Yes
Will you have to ride on snow? A good chance.
Does the road close, and do the locals go into hibernation or fly south? Of course not.
EO
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EurasiaOverland a memoir of one quarter of a million kilometres by road through all of the Former USSR, Western and Southern Asia.
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