The routes further east to Mashhad, and onwards to Zahedan, I´d find out more about safety situation there. Not many travellers choose that route. Actually I´m not sure if you even need permits for some areas there (one more thing to find out).
At least on the “main route”, that most people follow, from Bam to Pakistani border is a bit sketchy. I don´t know, if that extends to the north, but on that route, you would stay quite close to the Afghan border after Mashhad. Proximity to that border is one source of various sorts of trouble in the southeast of Iran.
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