Impossible question to answer. Its a big freakin continent and everyone is different in what they like.
I can tell you a couple of highlights from my trip.
Colombia (the whole country)
Staying in the Andes all the way through Peru and throw in the Cañon del Pato as well.
Salar de Uyuni and the Lagunas Route through Bolivia.
Remote altiplano routes in Bolivia and Argentina.
Remote Andean passes between Chile and Argentina.
Patagonia.
Beaches and mountains of southern Brasil.
The Guianas loop: French Guiana, Suriname, Guyana.
Gran Sabana in Venezuela.
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