YES, DO it!
I took a boat from Portbelo, Panama to Cartegena, Colombia, this Christmas. It wasn't in my original plan, it's just the way things worked out.
If you read all the post about Colombia I think you will find nothing but positive responses. It has been the highlight of my trip so far. Especially the people. My buddy Isaac and I were abducted by some Colombian bikers. We weren't allowed to pay for anything for two days of touring and eating around the Medellin area.
Neither of us wore a vest. No problems.
Do it.
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