There was a guy who rode the classical west-east route from the 1980s in 2017: from Bangui to Zongo, then on terrible tracks to Bukavu and into Rwanda.
I've almost no experience in Africa but am looking at west-east routes for a future trip all around Africa.
From what I understand it's not impossible but you need to be on top of changing security concerns, terrible road conditions, outbreaks of disease, civil unrest... the list goes on.
If you are an experienced traveller who does not mind some degree of risk, who can negotiate frustrating bureaucracy, deal with corrupt, money hungry, obstructive police, keep on top of local news and preferably speak French, I would say you have a good chance. If this is a new hobby, maybe start somewhere else.
EO
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EurasiaOverland a memoir of one quarter of a million kilometres by road through all of the Former USSR, Western and Southern Asia.
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