The F650 usually has TL marked tyres on a rim with a very tight safety bead, yet has tubes. You will struggle to do anything at the roadside. Can't plug them, can't carry the kit to get the tube out. You need a support van with a press!
Slime etc. put in before the puncture hides the failure until it's beyond the ability of the stuff to seal it. In my case the nail made little holes which sealed but then joined to make a flap which didn't. Try it after the nail makes one hole and you have a chance.
If you can't run to a tubeless conversion at least get TT tyres on and lubed and try the levers at home.
Andy
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