Some good advice in other posts.
In general it's not so much a matter of City A being safer than City B as a case of specific areas in each city are more problematic than others. As noted, there were some challenges in the first 18 months of the pandemic (if you can no longer feed yourself or your family you'll do what you can to respond to this) however things have improved somewhat. In general common sense precautions will keep you safe enough.
Although you obviously don't want to publish a detailed itinerary, where are you thinking of going? Small towns are essentially safe, the countryside (except for active fighting for narco territory in certain areas) safe enough, and the areas you are most likely to visit in the cities safe enough as well.
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