Mid May is blisteringly hot, as is early June in Northern India. You'll be drinking 5 litres of water a day, if you can ride through it. Apart from the regular monsoon beginning mid may in South India the NE region also has rain in winter.
Once the rains set in the road surfaces can deteriorate rapidly - and in most places they will not be repaired properly till October.
If ladakh is on your agenda, then April to end Oct makes sense thru the all weather road via Kargil - the more interesting Manali route opens only in July, and closes officially by Oct.
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