Speaking generally, I can't see why not, when you consider that the likes of Ed Marsh and Nathan Millward, to name just two have travelled huge distances on teeny Hondas then there's no reason why a125cc shouldn't.
I'm going to throw in the Derbi Terra Adventure as well. It's a125cc, Piaggio group bike with adventure bike specs and they've proved their metal in the Mongol Rally, in Ferando Retor's trips round Europe and into the Sahara too.
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Happiness has 125 cc
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