You can do the M41 on a chopper...
However, if you venture off that road, which I encourage you to do, you'll be able to do it without too much problems on a transalp if you know how to ride it and if you have some experience in light off road.
But I share Noah's reply, the more 'adventure' you want, the lighter th bike needs to be. But your question was about the Pamir Highway, and that's absolutely not a problem. You'll only maybe struggle between KG and TJ border as the road there can be shitty.
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